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We leverage artificial intelligence and machine learning methods to assist in screening skin lesions, to achieve earlier and more accurate precision diagnosis of skin cancers and other skin disorders. We also analyze how the intersection of environment, behavior, genetics and clinical factors can initiate and influence the outcomes of skin cancers and other skin disorders. Disease paradigms studied by our group that illustrate this intersection: an aggressive skin cancer called melanoma, and common inflammatory skin disorders, such as atopic dermatitis (eczema), psoriasis and acne.